Nuclear microenvironment in cancer: Control through liquid‐liquid phase separation

Crystal templating through liquid-liquid phase separation.

Controlled induction of crystal nucleation is a highly desirable but elusive goal. Attempts to speed up crystallization, such as high super saturation or working near a liquid-liquid critical point, always led to irregular and uncontrollable crystal growth. Here, we show that under highly nonequilibrium conditions of spinodal decomposition, water crystals grow as thin wires in a template-less f...

A Phase Separation Model for Transcriptional Control

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting...

Morphology control for nano-phase separation structures

In recent years, morphology control has emerged as an important research topic in many fields such as chemistry, biology, and medicine for the development of highly efficient materials and functional structures of devices based on organic and inorganic materials and their hybrids. Once developed, these techniques will pave the way for a wide range of possibilities such as the creation of highly...

Phase separation of composite materials through simultaneous polymerization and crystallization

Composite materials have attracted much interest because of the emergent properties originating from the components. A variety of methods have been studied to control the morphology of composites based on noncrystalline polymers and crystalline materials. However, it is not easy to control complex morphologies, such as segregated sea-island structures, on the submicrometer scale. Polymerization...

Phase Separation through Simultaneous Polymerization and Crystallization for Composite Materials